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And, if present, do they play a job in insulin and glucagon secretion? Blocking the transport of FFAR4 from the cytoplasm into the primary cilia reversed this effect — confirming the position of the primary cilia in insulin secretion. Jackson, Kim, and postdoctoral scholar Chien-Ting Wu, MD, PhD, knew that a household of signaling receptors referred to as G-protein coupled receptors, or GPCRs, are necessary for beta cell perform, and therefore insulin secretion. In 2019, molecular biologist Peter Jackson, PhD, showed that a molecule known as FFAR4, which is found on the first cilia of cells referred to as preadipocytes stimulates the formation of fats cells that squirrel away saturated fats from the blood. But I’m betting that the majority budding illustrators would omit a singular stubby protrusion, referred to as the primary cilia, present on almost all our cells. One GPCR particularly, the receptor for a molecule referred to as GLP-1 that’s produced in the intestines after a meal and stimulates insulin output, is the goal of many existing diabetes medicine. By analyzing mouse beta and alpha cells, they identified several GPCRs on the primary cilia, considered one of which was Jackson’s previous good friend, FFAR4.

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And, if present, do they play a job in insulin and glucagon secretion? Blocking the transport of FFAR4 from the cytoplasm into the primary cilia reversed this effect — confirming the position of the primary cilia in insulin secretion. Jackson, Kim, and postdoctoral scholar Chien-Ting Wu, MD, PhD, knew that a household of signaling receptors…

And, if present, do they play a job in insulin and glucagon secretion? Blocking the transport of FFAR4 from the cytoplasm into the primary cilia reversed this effect — confirming the position of the primary cilia in insulin secretion. Jackson, Kim, and postdoctoral scholar Chien-Ting Wu, MD, PhD, knew that a household of signaling receptors…